B.S. in Microbiology (1991) from the Tokyo University of Agriculture and Technology, Japan. Ph.D. in Production Science and Technology (1996) from Chiba University, Japan.
1. Fujii, S. and Amrein, H. (2010) Ventral lateral and DN1 clock neurons mediate distinct properties of male sex drive rhythm in Drosophila. Proc. Natl. Acad. Sci. USA. 23, 10590-10595.
2. Fujii, S., Toyama, A. and Amrein, H. (2008) A male-specific fatty acid omega-hydroxylase, SXE1, is necessary for efficient male mating in Drosophila melanogaster. Genetics 180, 179-90.
3. Fujii, S., Krishnan, P., Hardin, P. and Amrein, H. (2007) Nocturnal male sex drive in Drosophila. Curr. Biol. 17, 244-51.
4. Fujii, S. and Amrein, H. (2002) Genes expressed in the Drosophila head reveal a role for fat cells in sex-specific physiology. EMBO J. 21, 5353-63.
My main interest is to understand the molecular mechanisms by which intercellular signaling molecules modulate physiology of neural circuits controlling complex behaviors. I use male courtship behavior in Drosophila as a model system to identify and characterize genes and neurons that modulate this behavior by using genome-wide expression analysis combined with high-throughput behavioral monitoring systems. I demonstrated that the clock neurons modulate courtship behavior in a circadian manner through yet to be identified signaling molecules. Non-neuronal cells also modulate sexually dimorphic physiology and behavior through male-specific secreted proteins, but the target neurons of these proteins are currently unknown. Understanding the modulation potential in the fly courtship circuit and sexual behavior in general may provide new insight into the mechanisms of behavioral modulation in other animals, including mammals.